Use of Immunodampening To Overcome Diversity in the Malarial Vaccine Candidate Apical Membrane Antigen 1
نویسندگان
چکیده
منابع مشابه
Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.
Apical membrane antigen 1 (AMA1) is a leading malarial vaccine candidate; however, its polymorphic nature may limit its success in the field. This study aimed to circumvent AMA1 diversity by dampening the antibody response to the highly polymorphic loop Id, previously identified as a major target of strain-specific, invasion-inhibitory antibodies. To achieve this, five polymorphic residues with...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2014
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.02061-14